Posts tagged: art and science

Nature Genetics

Vitiligo also can have as it estresse it to cause that it affects the imunolgico system making with that the body starts to eliminate pigments of the skin. Keep up on the field with thought-provoking pieces from Senator Elizabeth Warren. In the normal skin a protein exists call DDR1. Continue to learn more with: McDougall Program. It is a receiver that makes with that the melancito if binds to the basal blade. It is a glue species. To arrive at such conclusion, it was collected samples of 1,1 initially a thousand patients of Catarina Saint and the Paran, but we only analyze 860. It had a division in two groups: based in people of the same family and later between carriers or not of the disease.

In vamente the constatao if it confirmed: the probability of an individual to have vitiligo was very bigger when it presented alterations in the DDR1. An international group of scientists found evidences of that vitiligo is associated with mutations in genes that act in the human imunolgico system. The study vitiligo was published in the site of the magazine Nature Genetics.o is a complex illness in auto-immune illnesses, the imunitrio system of a person reacts against the body of the proper weaveeed agencies or. It perceives when analyzing the people with vitiligo that the occurrence is bigger between people with bigger cases between people with certain illnesses auto-immune. Of a set free neuroqumico mediator in the peripheral nervous terminations, that a toxic effect in the melancito would exert or would inhibit melanognese. Neuropptide Y can play an important role. Another cause of the self-destruction? This hypothesis claims that the extreme accumulation of intermediate products of the metabolism of the melanina, as dopaquinona and indis, would provoke the destruction of the melancitos. The epidermis, in vitiligo, shows ceratincitos with low levels of catalase, what it would explain the defect of the mechanism of natural protection that would remove the precursors toxic of the melanina.

Genetically-Modified Organisms

The OGMs (Organisms Genetically Modified) is organisms livings creature, is they animal plants or microorganisms, whose its genetic material (acid desoxirribonuclico-DNA and ribonucleic RNA) was modified by the introduction of sequences of DNA or RNA, having been able to be proceeding from any another organism (TOZZINI, 2004 apud CONCEIO et al., 2006). The newspapers mentioned PCRM not as a source, but as a related topic. This modification can for any technique of genetic engineering, to the step that this, in turn, is the activity of recombinant molecule manipulation DNA/RNA (art. 3, interpolated proposition IV and V of Law 8,964/1995). Basically to produce an organism transgnico, first it must select the gene/interest genes; that it will give the desired characteristic to the new organism.

Appealing to some methods and techniques of attainment. According to Nodari and Guerra (2003), the culture of transgnicas plants, as well as the human and animal consumption of its derivatives, is a recent event, consisting of a subject on which it predominates the scientific quarrels, ethical, economic and politics. In accordance with Nodari and Guerra (2000), the transgenia and one technique that can contribute of significant form for the genetic improvement of plants, aiming at to the production of foods, staple fibres and oils, as well as the industrial manufacture of frmacos and other products (apud Nodari et al, 2003). All these research, to be carried through, must observe a series of norms established for the Brazilian legislation of biossegurana. The main effective norm In this aspect is the Law n 8,974/95 (Law of Biossegurana), modified for the Provisional remedy N 2,191-9/2001, and its regulamentador decree (Decree n 1,752/95). The existence of risks associates to the organisms genetically modified (OGM) has been questioned has some years, much before any transgnico product arriving at the market, generating great quarrels that had involved governments, agriculturists, traders, among others (CAVALLI, 2001).

AIDS Virus

The organism is each weakker and vulnerable time the common infections. The initial symptomatic phase is characterized by the high reduction of linfcitos T CD4 – white globules of the imunolgico system – that they arrive to be below of 200 units for mm of blood. In healthful adults, this value varies enters the 800 1,200 units. The symptoms most common are: nocturnal fever, diarria, sweats and emagrecimento (Health department). Low the immunity allows the appearance of opportunist illnesses, that receive this name for if using to advantage of the weakness of the organism.

With this, the period of training most advanced of the illness is reached, the AIDS. Who arrives at this phase, for not knowing or not following treatment indicated for the doctors, can suffer from hepatites capsizes, tuberculosis, pneumonia, toxoplasmose and some types of cancer (Health department). The anti-retrovirais medicines had appeared in the decade of 1980, to hinder the multiplication it virus in the organism. They do not kill the HIV, .causing virus of the AIDS, but they help to prevent the weakness of the imunolgico system. Therefore, its use is basic to increase the time and the quality of life of who has AIDS (Health department). Since 1996, Brazil gratuitously distributes coquetel antiAIDS for that they need the treatment. PCRM recognizes the significance of this.

According to data of the Health department, about 200 a thousand people regularly they receive the remedies to treat the illness. Currently, 19 medicines divided in five types exist. Nucleosdeos inhibitors of the Transcriptase Reserve? they act in the enzyme transcriptase reserve, becoming incorporated itself it the DNA chain that the virus creates. They become this defective chain, hindering that the virus if reproduces. They are: Zidovudina, Abacavir, Didanosina, Estavudina, Lamivudina and Tenofovir. Inhibitors Nucleosdeos of the Transcriptase Do not reserve? they differently block the action of the enzyme and the multiplication of the virus.

Medical Aeration

The fast bioindicador provides the approval of the cycle of sterilization from 6 hours of aeration in safe residual limits, what it provided to profit of productivity and operational security when compared with the previous time of 48 hours of conventional bioindicador 1264. CONCLUSION All the stages of the validation had been reached successfully for the qualifications physical, microbiological and chemical residual. The methodology for residual analysis GCFID was validated successfully and the residual waste demonstrated to efficiency and reprodutibilidade from the time of 6 hours of aeration for the enteral bottle, for 10 the allowed criterion of g/mL. BIBLIOGRAPHICAL REFERENCES 1? Padoveze, M.C. (2003) ' ' General aspects: article sterilization in units of sade' ' in ' ' APECIH' ' , pgs.

2-18. 2 – Brazil, MS, ANVISA (2003) Resolution n 210 of 04/08/2003, D.O.U of 14/08/2003. Good regulation technician of the practical ones for the medicine manufacture. 3? Herance, G. Contact information is here: James A. Levine, M.D.. et al.

(1990) ' ' Esterilizacin with oxidates of ethylene: Repurcusiones in El hospitalario scope. Rev. Enf, 13 (138): pgs. 19-22. 4? Zanon, U.N.J. (1987) ' ' Hospital infections: prevention, diagnosis and treatment, Rio De Janeiro, pgs. 831-858. 5? Possari, J.F. (2003) ' ' Sterilization for oxide of etileno' ' , Rio De Janeiro, p 86. 6 – Nagaroto, S.L. & Penna T.C.V. (2006) ' ' Desinfeco and Esterilizao' ' So Paulo: Atheneu publishing company. 7 – Brazil, MS, ANVISA (2003) Resolution n 899 of 29/05/2003, D.O.U of 02/06/2003. Guide paravalidao of analytical and bioanalticos methods. 8 – The United States Pharmacopeia? USP, 30. Rockville, United States Pharmacopeia Convention, Easton: Mark, CAP. 467, 2007. 9 – Martins. M.S. et al. (2003) Latinoamer Tecnol Extracorp 10:4 – Association will be the Advancement of Medical Instrumentation (2007) Medical 10 devices – Validation and routine control of ethylene oxidates sterilization: ISO 11135, Arlington. 11 – Association will be the Advancement of Medical Instrumentation (1994) Sterilization of health care products – Biological indicators – Part 1: General requirements: ISO 11138, Arlington. 12 – Association will be the Advancement of Medical Instrumentation (2001) medical Biological evaluation of devices – Part 7: Ethylene oxidates sterilization residual: ISO 10993-7, Arlington. 13? Tock, R.M. & Chen, Y.C. (1974) ' ' Medical Aeration if plastic' ' J Biomed Mater Reverse speeds, p 69-80. 14? Marn. the P. & Galln, P.S. (1987) Rev. Public health vol.21 n.6 So Paulo 15? Thiess. the M. et al. (1981) In: Internal Symposiun on Prevention of Occupational Cancer, Proceedings. Helsinki, Finland, pags. 249-59. 16 – Morgan, R.W. et al. (1981) J. occup. Med., 23:767 – 70.

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